A Fatal Case of Levamisole-Induced Vasculitis
نویسندگان
چکیده
Levamisole is an antihelminthic agent used mainly by veterinarians that is now commonly used as an adulterant in cocaine [1]. Numerous case reports have connected levamisole with vasculitis and neutropenia [2, 3]. Our case focuses on a patient who used weekly cocaine contaminated with levamisole and developed necrosis of the skin in her lower extremities, abdomen, and lower back. To our knowledge, this is also the only case of levamisoleinduced vasculitis with leukocytosis, as neutropenia appears to be the typical finding.
منابع مشابه
Clinical & Medical Imaging Title: Levamisole induced Vasculopathy: A Case of Extensive Necrosis after Re-exposure to Levamisole Tainted Cocaine
Levamisole induced skin vasculitis/vasculopathy is a relatively new diagnosis with limited knowledge about the underlying mechanism of above manifestation. The most commonly reported cause is the generation of autoantibodies against myleoperoxidase and other neutrophilic enzymes hence commonly mimicking ANCA associated vasculitis. We present a case report of 52 years old female with history of ...
متن کاملp-ANCA-Associated Vasculitis Caused by Levamisole-Adulterated Cocaine: A Case Report
A rare case of a patient with an unusual skin rash after using cocaine is presented. A clinical diagnosis of levamisole-induced vasculitis was made based on initial presentation of purpuric skin lesions involving the ears and positive cocaine on urine toxicology screening. The diagnosis was confirmed after laboratory findings of neutropenia, positive serum levamisole, and a histopathologic test...
متن کاملLevamisole tainted cocaine induced vasculitis
Levamisole has been implicated in the vasculitis and aganulocytosis. It has been pulled from the United States market for human use. Due to its euphoric and bulking properties, it has been . used as a bulking agent in cocaine. We hereby present a case of a 56-year-old Hispanic male, who developed vasculitis due to cocaine use adulterated with levamisole.
متن کاملPurpuric skin eruption in an illicit drug user: Levamisole-induced vasculitis.
© 2017 Kristen Whitworth. Cavalieri. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License. The first case connecting vasculitis to levamisole adulterated cocaine was published in 2010. Since that time, there have been numerous case reports of complications arising from levamisole contaminated cocaine. A case report in 2011 suggested the use o...
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BACKGROUND Levamisole is a common adulterant of cocaine. It can cause agranulocytosis and cutaneous vasculitis that can possibly lead to cutaneous necrosis. In all reported cases of levamisole-induced vasculitis, it has been described as a clinical syndrome characterized by a constellation of typical clinical features and a positive serum serology for ANCA levels, especially very high-titer p-A...
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